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close this bookGuidelines for the Treatment of Malaria (WHO; 2006; 266 pages) View the PDF document
View the documentGlossary
View the documentAbbreviations
open this folder and view contents1. Introduction
View the document2. The clinical disease
open this folder and view contents3. Treatment objectives
open this folder and view contents4. Diagnosis of malaria
open this folder and view contents5. Resistance to antimalarial medicines9
open this folder and view contents6. Antimalarial treatment policy
open this folder and view contents7. Treatment of uncomplicated P. Falciparum malaria10
open this folder and view contents8. Treatment of severe falciparum malaria14
close this folder9. Treatment of malaria caused by P. vivax, P. ovale or P. malariae19
View the document9.1 Diagnosis
View the document9.2 Susceptibility of P. vivax, P. ovale and P. malariae to antimalarials
View the document9.3 Treatment of uncomplicated vivax malaria
View the document9.4 Treatment of severe vivax malaria
View the document9.5 Treatment of malaria caused by P. ovale and P. malariae
View the document9.6 Monitoring therapeutic efficacy for vivax malaria
View the document10. Mixed malaria infections
open this folder and view contents11. Complex emergencies and epidemics
open this folder and view contentsAnnexes
 

9.4 Treatment of severe vivax malaria

Although P. vivax malaria is considered to be a benign malaria, with a very low case-fatality ratio, it may still cause a severe and debilitating febrile illness. It can also very occasionally result in severe disease as in falciparum malaria. Severe vivax malaria manifestations that have been reported are cerebral malaria, severe anaemia, severe thrombocytopenia and pancytopenia, jaundice, spleen rupture, acute renal failure and acute respiratory distress syndrome. Severe anaemia and acute pulmonary oedema are not uncommon. The underlying mechanisms of severe manifestations are not well understood.

Prompt and effective treatment and case management should be the same as for severe and complicated falciparum malaria (see section 8).

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