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close this bookGuidelines for the Treatment of Malaria (WHO; 2006; 266 pages) View the PDF document
View the documentGlossary
View the documentAbbreviations
open this folder and view contents1. Introduction
View the document2. The clinical disease
open this folder and view contents3. Treatment objectives
open this folder and view contents4. Diagnosis of malaria
open this folder and view contents5. Resistance to antimalarial medicines9
open this folder and view contents6. Antimalarial treatment policy
open this folder and view contents7. Treatment of uncomplicated P. Falciparum malaria10
open this folder and view contents8. Treatment of severe falciparum malaria14
close this folder9. Treatment of malaria caused by P. vivax, P. ovale or P. malariae19
View the document9.1 Diagnosis
View the document9.2 Susceptibility of P. vivax, P. ovale and P. malariae to antimalarials
View the document9.3 Treatment of uncomplicated vivax malaria
View the document9.4 Treatment of severe vivax malaria
View the document9.5 Treatment of malaria caused by P. ovale and P. malariae
View the document9.6 Monitoring therapeutic efficacy for vivax malaria
View the document10. Mixed malaria infections
open this folder and view contents11. Complex emergencies and epidemics
open this folder and view contentsAnnexes
 

9.5 Treatment of malaria caused by P. ovale and P. malariae

Resistance of P. ovale and P. malariae to antimalarials is not well characterized and infections caused by these two species are considered to be generally sensitive to chloroquine. Only one study, conducted in Indonesia, has reported resistance to chloroquine in P. malariae. The recommended treatment for the relapsing malaria caused by P. ovale is the same as that given to achieve radical cure in vivax malaria, i.e. with chloroquine and primaquine. P. malariae should be treated with the standard regimen of chloroquine as for vivax malaria, but it does not require radical cure with primaquine as no hypnozoites are formed in infection with this species.

P. ovale mainly occurs in areas of high stable transmission where the risk of re-infection is high. In such settings, primaquine treatment is not indicated.

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