Resistance of P. ovale and P. malariae to antimalarials is not well characterized and infections caused by these two species are considered to be generally sensitive to chloroquine. Only one study, conducted in Indonesia, has reported resistance to chloroquine in P. malariae. The recommended treatment for the relapsing malaria caused by P. ovale is the same as that given to achieve radical cure in vivax malaria, i.e. with chloroquine and primaquine. P. malariae should be treated with the standard regimen of chloroquine as for vivax malaria, but it does not require radical cure with primaquine as no hypnozoites are formed in infection with this species.
P. ovale mainly occurs in areas of high stable transmission where the risk of re-infection is high. In such settings, primaquine treatment is not indicated.