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close this bookGuidelines for the Treatment of Malaria (WHO; 2006; 266 pages) View the PDF document
View the documentGlossary
View the documentAbbreviations
open this folder and view contents1. Introduction
View the document2. The clinical disease
open this folder and view contents3. Treatment objectives
open this folder and view contents4. Diagnosis of malaria
open this folder and view contents5. Resistance to antimalarial medicines9
open this folder and view contents6. Antimalarial treatment policy
open this folder and view contents7. Treatment of uncomplicated P. Falciparum malaria10
open this folder and view contents8. Treatment of severe falciparum malaria14
open this folder and view contents9. Treatment of malaria caused by P. vivax, P. ovale or P. malariae19
View the document10. Mixed malaria infections
open this folder and view contents11. Complex emergencies and epidemics
open this folder and view contentsAnnexes
 

10. Mixed malaria infections

Mixed malaria infections are common. In Thailand, despite low levels of malaria transmission, one-third of patients with acute P. falciparum infection are co-infected with P. vivax, and 8% of patients with acute vivax malaria have simultaneous P. falciparum infection. Mixed infections are underestimated by routine microscopy. Cryptic P. falciparum infections can be revealed in approximately 75% of cases by the RDTs based on the histidine-rich protein 2 (HRP2) antigen, but such antigen tests are much less useful (because of their lower sensitivity) in detecting cryptic vivax malaria. ACTs are effective against all malaria species and are the treatment of choice. Radical treatment with primaquine should be given to patients with confirmed P. vivax and P. ovale infections except in high transmission settings where the risk of re-infection is high.

 

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