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close this bookGuidelines for the Treatment of Malaria (WHO; 2006; 266 pages) View the PDF document
View the documentGlossary
View the documentAbbreviations
open this folder and view contents1. Introduction
View the document2. The clinical disease
open this folder and view contents3. Treatment objectives
open this folder and view contents4. Diagnosis of malaria
open this folder and view contents5. Resistance to antimalarial medicines9
open this folder and view contents6. Antimalarial treatment policy
open this folder and view contents7. Treatment of uncomplicated P. Falciparum malaria10
open this folder and view contents8. Treatment of severe falciparum malaria14
open this folder and view contents9. Treatment of malaria caused by P. vivax, P. ovale or P. malariae19
View the document10. Mixed malaria infections
close this folder11. Complex emergencies and epidemics
View the document11.1 Diagnosis
View the document11.2 Use of rapid diagnostic tests in epidemic situations
View the document11.3 Management of uncomplicated malaria in epidemics
View the document11.4 Areas prone to mixed falciparum/vivax malaria epidemics
View the document11.5 Use of gametocytocidal drugs to reduce transmission
View the document11.6 Anti-relapse therapy in vivax malaria epidemics
View the document11.7 Mass treatment
open this folder and view contentsAnnexes

11.7 Mass treatment

Mass treatment (mass drug administration) of all or a large section of the population whether symptoms are present or not) has been carried out in the past, usually in conjunction with insecticide residual spraying, as a way of controlling epidemics. Analysis of 19 mass drug administration projects during the period 1932-1999 did not draw definitive conclusions because study designs were so variable.20 Many projects were unsuccessful, although a reduction in parasite prevalence and some transient reduction in mortality and morbidity occurred in some cases. Reduced transmission was seen only in one study, in Vanuatu, where the population concerned was relatively small, well defined and controlled.

20 von Seidlein L, Greenwood BM. Mass administration of antimalarial drugs. Trends in Parasitology, 2003, 19:790-796.

There is no convincing evidence for the benefits of mass treatment. Mass treatment of symptomatic febrile patients is considered appropriate in epidemic and complex emergency situations. Whenever this strategy is adopted, a full treatment course should be given.


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