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close this bookGuidelines for the Treatment of Malaria (WHO; 2006; 266 pages) View the PDF document
View the documentGlossary
View the documentAbbreviations
open this folder and view contents1. Introduction
View the document2. The clinical disease
close this folder3. Treatment objectives
View the document3.1 Uncomplicated malaria
View the document3.2 Severe malaria
open this folder and view contents4. Diagnosis of malaria
open this folder and view contents5. Resistance to antimalarial medicines9
open this folder and view contents6. Antimalarial treatment policy
open this folder and view contents7. Treatment of uncomplicated P. Falciparum malaria10
open this folder and view contents8. Treatment of severe falciparum malaria14
open this folder and view contents9. Treatment of malaria caused by P. vivax, P. ovale or P. malariae19
View the document10. Mixed malaria infections
open this folder and view contents11. Complex emergencies and epidemics
open this folder and view contentsAnnexes

3.1 Uncomplicated malaria

The objective of treating uncomplicated malaria is to cure the infection. This is important as it will help prevent progression to severe disease and prevent additional morbidity associated with treatment failure. Cure of the infection means eradication from the body of the infection that caused the illness. In treatment evaluations in all settings, emerging evidence indicates that it is necessary to follow patients for long enough to document cure (see section 6.1). In assessing drug efficacy in high-transmission settings, temporary suppression of infection for 14 days is not considered sufficient by the group.

The public health goal of treatment is to reduce transmission of the infection to others, i.e. to reduce the infectious reservoir.4

4 Further information on antimalarials and malaria transmission is provided in Annex 4.

A secondary but equally important objective of treatment is to prevent the emergence and spread of resistance to antimalarials. Tolerability, the adverse effect profile and the speed of therapeutic response are also important considerations.

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